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You Searched For: Etoposide,+[3H]


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Image Unavailable-75789-178

Human Recombinant Heat Shock beta 11 (from E. coli)

Catalog Number: (75789-178)
Supplier: Prosci
Description: Heat Shock Protein beta -11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death that correlated with a decreased release of mitochondrial Cytochrome C into the cytosol. Inhibition of HSP90 function completely abrogated the protective effect of HSPB11. This data suggests that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.
Image Unavailable-102992-670

SAR-020106 ≥95%

Supplier: Adipogen
Description: SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.

Image Unavailable-76081-406

Anti-SERINC3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76081-406)
Supplier: Bioss
Description: TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.
Product Image-89357-904

Anti-BIRC7 Rabbit Polyclonal Antibody

Catalog Number: (89357-904)
Supplier: Genetex
Description: The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq]
Image Unavailable-10427-038

Anti-SERINC3 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10427-038)
Supplier: Bioss
Description: TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.
Image Unavailable-102987-852

Lovastatin

Supplier: Adipogen
Description: Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest).

Product Image-BDH7778-1

Potassium pyroantimonate USP Test Solution (TS) 1 analytical reagent, VWR Chemicals BDH®

Catalog Number: (BDH7778-1)
Supplier: VWR International
Description: Prepared and tested in accordance with the US Pharmacopeia and the European Pharmacopeia.

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Product Image-BDH9278-2.5KG

Sodium acetate trihydrate 99.0-101.0% ACS, VWR Chemicals BDH®

Supplier: VWR International
Description: Meets reagent specifications for testing USP/NF monographs.

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Product Image-BDH7342-2

Phenolphthalein solution 0.5%, VWR Chemicals BDH®

Supplier: VWR International
Description: Made with 50% isopropanol.

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Product Image-BDH7344-4

Phenolphthalein 1% in alcohol, VWR Chemicals BDH®

Supplier: VWR International
Description: Made with denatured ethanol.

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Image Unavailable-89130-184

Azure A for Gram staining

Catalog Number: (89130-184)
Supplier: VWR International
Description: Used in histological staining of tissues.

Certificates Minority or Woman-Owned Business Enterprise Product available on GSA Advantage®


Product Image-10863-274

Eosin Y alcoholic solution molecular biology stain

Catalog Number: (10863-274)
Supplier: VWR International
Description: This fast-acting, alcoholic counterstain stains erythrocytes, collagen, and the cytoplasm of muscle (epithelial cells) different shades of pink

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Product Image-10143-130

Eosin Y (yellowish) 1% alcoholic solution, VWR® stain for histology, for cytology

Supplier: VWR International
Description: Eosin Y 1% Alcoholic is a cytoplasmic stain that when used in the hematoxylin and eosin staining procedure provides excellent definition of cell components in shades of red and pink.

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Product Image-10143-136

Eosin Y (yellowish) 1% alcoholic solution Intensified, VWR® stain for histology, for cytology

Supplier: VWR International
Description: Eosin Y 1% Alcoholic is a cytoplasmic stain that when used in the hematoxylin and eosin staining procedure provides excellent definition of cell components in shades of red and pink.

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Product Image-101973-900

Tetracycline, [7-3H] 95

Supplier: MORAVEK BIOCHEMICALS MS
Description: Tetracycline, [7-3H] 95

Product Image-BDH7392-2

Bromophenol blue 0.04% (w/v) in aqueous solution, VWR Chemicals BDH®

Catalog Number: (BDH7392-2)
Supplier: VWR International
Description: Made with deionized water.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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