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Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75909-732

Supplier: Biotium

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Description: CD27Monoclonal antibody, Clone: 203.6, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Isotype: IgG3, kappa, Immunogen: Sezary cells, Synonyms: T14, TNFRSF7, TNFSF7, Tp55, Application: IF, FC, Size: 500 uL

Catalog Number: 75891-622

Supplier: Biotium

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Description: Vimentin, Monoclonal antibody, Clone: VM1170, Host: Mouse, Species reactivity: Mouse, Pig, Cow, Cat, Sheep, Rat, Human, Rabbit, Isotype: IgM, Conjugate: CF405S, Immunogen: Human thymic nuclear extract, Synonyms: VIM, Application: IF, Size: 100uL

Catalog Number: 75979-402

Supplier: Biotium

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Description: MemBrite™ Fix cell surface staining kits are designed for covalently staining the surface of live cells to conveniently visualize cell boundaries in immunofluorescence experiments.

Catalog Number: 76403-926

Supplier: Biotium

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Description: CD59 Monoclonal antibody, Clone: MACIF/629, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: BSA-free, Immunogen: Recombinant full-length human CD59 protein, Application: Immunofluorescence, Immunohistology, Size: 50 uL

Catalog Number: 75917-066

Supplier: Biotium

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Description: P27 / KIP1, Monoclonal antibody, Clone: SX53G8), Host: Mouse, Species reactivity: Mouse, Monkey, Rat, Human, Isotype: IgG's, Conjugate: CF568, Immunogen: Mouse recombinant p27 protein (DCS-72.F6), Synonyms: CDKN1B, CDKN4, Cyclin Dependent Kinase Inhibitor 1B, Size: 500uL

Catalog Number: 75968-960

Supplier: Biotium

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Description: This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75952-000

Supplier: Biotium

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Description: The epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Catalog Number: 75972-884

Supplier: Biotium

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Description: This antibody recognizes a protein of 110 kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75881-820

Supplier: Biotium

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Description: This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells. Deoxyribonucleic acid (DNA) is a nucleic acid that stores long-term information regarding the development and function of all known living organisms. DNA consists of two long nucleotide polymers, which are composed of four bases, namely adenine, thymine, guanine and cytosine, all of which are flanked by a phosphate-deoxyribose backbone. Normally, DNA exists as a double-stranded (ds) molecule that forms in the shape of a double helix, allowing the bases and the backbone of the two strands to interact, thus forming a polynucleotide. When the double helix is unwound (either by enzymes or heat), DNA exists as a single-stranded (ss) molecule that is less stable than the double helix, but is necessary for protein access to DNA bases. Double stranded DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75924-304

Supplier: Biotium

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Description: This antibody recognizes a protein of 40-45 kDa, identified as human milk fat globule membrane protein (HMFG). HMFG is present on normal human breast epithelial cells and cell lines derived from breast carcinomas, as well as to the outer surface of the human milk fat globule. HMFG is considered as a differentiation marker. It is useful as specific breast epithelial marker and can also provide a tool to study the role of the cell surface in normal and neoplastic mammary development.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: 75961-288

Supplier: Biotium

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Description: CMV-p65 Monoclonal antibody, Clone: CMV100, Host: Mouse, Species reactivity: CMV, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Recombinant CMV-p65 protein, Application: IF, Immunohistology (formalin), Immunohistology (frozen), Size: 500 uL

Catalog Number: 75922-862

Supplier: Biotium

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Description: The simplicity and convenience of Mix-n-Stain™ labeling of nanobodies with fluorescent CF® dyes or biotin.

Catalog Number: 76423-366

Supplier: Biotium

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Description: Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This MAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained.Immunohistochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75920-898

Supplier: Biotium

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Description: MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MUC18/1130, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: CF488A, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Catalog Number: 75964-138

Supplier: Biotium

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Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405M is a blue fluorescent dye (Ex/Em 408/452 nm) with superior brightness and photostability compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75910-000

Supplier: Biotium

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