Description: Liver CanuliculI, Monoclonal antibody, Clone: HSA98, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: CF594, Immunogen: HEP-3B human hepatocellular carcinoma cells, Application: Immunofluorescence, Size: 100uL

Catalog Number: 75957-102

Supplier: Biotium

Sale

Description: This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Catalog Number: 75955-740

Supplier: Biotium

Sale

Description: TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Membrane-enriched fraction of breast carcinoma, Synonyms: CA72.4, Size: 100uL

Catalog Number: 75974-678

Supplier: Biotium

Sale

Description: bcl-x Monoclonal antibody, Clone: BX006 + 2H12, Host: Mouse, Species reactivity: Mouse, Pig, Rat, Human, Isotype: IgG2a, Conjugate: purified, Immunogen: A synthetic peptide, aa 3-14, Synonyms: B cell lymphoma 2 like, BCL XL/S, Application: IF, IHC, FC, Size: 100uL

Catalog Number: 75885-238

Supplier: Biotium

Sale

Description: bcl-x Monoclonal antibody, Clone: BX006, Host: Mouse, Species reactivity: Mouse, Pig, Rat, Human, Isotype: IgG2a, Conjugate: purified, Immunogen: A synthetic peptide, aa 3-14, Synonyms: BCL XL/S, BCL-2-like protein 1, Bcl2-L, Application: IF, IHC, FC, Size: 500 uL

Catalog Number: 75885-176

Supplier: Biotium

Sale

Description: Milk Fat Globulin, Monoclonal antibody, Clone: MFG-06, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Human milk fat globule membrane preparation, Synonyms: HMFG; Lactadherin, Application: IF, Size: 500uL

Catalog Number: 75961-358

Supplier: Biotium

Sale

Description: CD28 Monoclonal antibody, Clone: C28/77, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human CD28 protein, Synonyms: T-cell-specific surface glycoprotein CD28, Tp44, Application: IF, IHC, FC, Size: 100uL

Catalog Number: 75891-764

Supplier: Biotium

Sale

Description: This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75913-798

Supplier: Biotium

Sale

Description: This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75888-286

Supplier: Biotium

Sale

Description: SUMO-1, Monoclonal antibody, Clone: SUMO1/1188, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant human SUMO1 protein, Application: Immunofluorescence, Immunohistology (formalin), Western, Flow cytometry, Size: 100uL

Catalog Number: 75974-474

Supplier: Biotium

Sale

Description: Von Willebrand Factor, Monoclonal antibody, Clone: VWF635, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Application: IF, Size: 500uL

Catalog Number: 75979-720

Supplier: Biotium

Sale

Description: This MAb reacts with a 200 kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L), 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75965-600

Supplier: Biotium

Sale

Description: GelRed is a sensitive, stable and environmentally safe fluorescent nucleic acid dyes are DNA gel loading buffers designed to replace the highly toxic ethidium bromide for one-step fluorescent staining and gel loading of DNA.

Catalog Number: 10098-684

Supplier: Biotium

Sale

Description: This MAb reacts with a protein of 22 kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The beta subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®660R is a far-red fluorescent dye (Ex/Em 663/682 nm) with superior brightness and unrivaled photostability among spectrally similar dyes.

Catalog Number: 75952-536

Supplier: Biotium

Sale

Description: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Catalog Number: 75925-134

Supplier: Biotium

Sale

Description: Beta-2 microglobulin Monoclonal antibody, Clone: BBM.1, Host: Mouse, Species: Human, Non-human primates, Isotype: IgG2b, kappa, Conjugate: CF405S, Immunogen: Recognizes a protein of 12kDa, Synonyms: Hdcma22p, Application: IF, Immunohistology, Fc, Size: 500ul

Catalog Number: 75883-954

Supplier: Biotium

Sale