You Searched For: BIOTIUM, INC

Supplier: Biotium

Description: Hepatocyte Specific Antigen, Monoclonal antibody, Clone: HSA133, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: CF488A, Immunogen: SK-H1A9-2 human hepatocellular carcinoma cells, Application: Immunofluorescence, Size: 500uL

Supplier: Biotium

Description: This antibody recognizes a myeloid associated differentiation antigen in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell type in human tissues. Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. It reacts with early precursor and mature forms of human and monkey myeloid cells. This MAb is useful for the detection of myeloid leukemias and granulocytic sarcomas. It can be used as a marker of granulocytes in normal tissues or inflammatory processes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Supplier: Biotium

Description: Anti-IgG Rabbit Polyclonal Antibody (CF™ 594)

Catalog Number: (97065-678)

Supplier: Biotium

Description: A Highly Water-Soluble Cyanine-Based Dye That Yields The Brightest Fluorescence And Highest signal-to-noise ratio in immunostaining among spectrally similar dyes, such as cy*5.5, alexa fluor* 680, dylight* 680 and irdye* 680.

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Supplier: Biotium

Description: CD195 / CCR-5 Monoclonal antibody, Clone: 12D1, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Immunogen: Human native CCR5 protein, Isotype: IgG2a, kappa, Synonyms:Chemokine receptor CCR5, Application: IF, IHC (frozen), FC, Size: 500 uL

Supplier: Biotium

Description: EGFr Monoclonal antibody, Clone: B1D8, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: CF568, Immunogen: Microsomes from A431 cells, Synonyms: Erbb1, ERBB1, Application: FC, Affinity purification, IP, Size: 100uL

Catalog Number: (89139-564)

Supplier: Biotium

Description: APTS is a very useful green fluorescent dye for labeling glycoproteins or sugar molecules in general. The labeling occurs via reductive amination which involves the formation of a Schiff base between the amine of APTS and the aldehyde or ketone of the sugar, followed by the reduction of the Schiff base linkage to a stable carbon-nitrogen bond. The multi-anionic nature of the dye makes it ideal for the studies of carbohydrate molecules by high resolution capillary electrophoresis.

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Supplier: Biotium

Description: This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: This antibody recognizes a protein of 130-140 kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD . It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.

Supplier: Biotium

Description: This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: (75882-964)

Supplier: Biotium

Description: Calponin-1 Monoclonal antibody, Clone: CALP, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG's, Conjugate: BSA-free, Immunogen: Crude human uterus extract, Synonyms: CNN1, Cnn1, Application: IF, IHC, FC, Size: 50 uL

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Supplier: Biotium

Description: HCG-beta, Monoclonal antibody, Clone: HCGb/54, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: Recombinant hCG beta protein (HCGb/54 and HCGb/459), Synonyms: CG-beta; CGB3; CGB5; CGB7; CGB8, Application: Immunofluorescence, Size: 500uL

Catalog Number: (75969-208)

Supplier: Biotium

Description: P55;50 EBV-Early Antigen, Monoclonal antibody, Clone: 1108-1, Host: Mouse, Species reactivity: EBV, Isotype: IgG1, kappa, BSA-free, Synonyms: EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1, Application: Immunofluorescence, Size: 50 uL

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Supplier: Biotium

Description: TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 100uL

Supplier: Biotium

Description: TNF alphA, Monoclonal antibody, Clone: TNF655, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant human TNF-alpha, Application: Immunofluorescence, Flow cytometry, Size: 100uL