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Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 6-50 - are highly-alternating copolymers, well-suited for the generation of native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 6-50 gets its name from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general lighter AASTYs, like 6-50 tend to be more aggressive, while heavier AASTYs, such as 11-45 show higher thermodynamic stability.

The exact composition of AASTY copolymers shows different extraction efficiency, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs. As AASTY is made using controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation. Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.

Every membrane protein solubilization needs to undergo a screening process before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process we offer a handy Screening Kit for AASTYs to test them all. Additionally, we recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

Catalog Number: 77392-538

Supplier: CUBE BIOTECH

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Description: CAS Number: 3087-16-9 MDL Number: MFCD00012117 Molecular Formula: C27H26N2O7S2 Molecular Weight: 576.61 Form: Crystal Color: Deep Yellow Red

Catalog Number: TCG0250-25G

Supplier: TCI America

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Description: Acid green 50, pure

Catalog Number: TS19010-0250

Supplier: THERMO FISHER SCIENTIFIC CHEMICALS

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Description: ProShield® 50 garments are suitable for protection against non-hazardous particles, light liquid splash and aerosols in many industrial applications.

Catalog Number: 76187-516

Supplier: DuPont

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Description: Papanicolaou stains are used in conjunction with Hematoxylin nuclear stains in the diagnosis of malignant cytological diseases.

Catalog Number: 10143-158

Supplier: VWR International

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Description: Amberlite® CG-50 ion-exchange resin Type 1

Catalog Number: TS202115000

Supplier: THERMO FISHER SCIENTIFIC CHEMICALS

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Description: ProShield® 50 garments are suitable for protection against non-hazardous particles, light liquid splash and aerosols in many industrial applications.

Catalog Number: 76187-480

Supplier: DuPont

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Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 11-50 - are highly-alternating copolymers, well-suited for the generation of native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 11-50 gets its name from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general lighter AASTYs, like 6-45 tend to be more aggressive, while heavier AASTYs, such as 11-50 show higher thermodynamic stability.

Every membrane protein solubilization needs to undergo a screening process in before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process, we offer a handy Screening Kit for AASTYs to test them all.

We recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

Catalog Number: 77392-544

Supplier: CUBE BIOTECH

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Description: Cytoplasmic counterstain for Pap staining technique.

Catalog Number: 15204-216

Supplier: MilliporeSigma

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Description: ProShield® 50 garments are suitable for protection against non-hazardous particles, light liquid splash and aerosols in many industrial applications.

Catalog Number: 76187-528

Supplier: DuPont

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Description: LabReady™ Solvent Blends

Catalog Number: BJ492-4

Supplier: Honeywell Research Chemicals

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Description: ProShield® 50 garments are suitable for protection against non-hazardous particles, light liquid splash and aerosols in many industrial applications.

Catalog Number: 76187-524

Supplier: DuPont

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Description: Papanicolaou Stain Solution, EA-50 (EA Counterstain).

Catalog Number: 100504-424

Supplier: Electron Microscopy Sciences

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Description: Clearly differentiate cellular components with pink, green and blue-green hues utilizing Epredia™ Shandon™ EA-50 Stain.

Catalog Number: 89370-816

Supplier: Epredia

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Description: Control the color hues and intensities of your work with Epredia™ Papanicolaou EA Stain, useful for both gynecological and non-gynecological staining.

Catalog Number: 84000-120

Supplier: Epredia

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Description: ProShield® 60 garments are suitable for protection against non-hazardous particles, light liquid splash and aerosols in many industrial applications.

Catalog Number: 13452-326

Supplier: DuPont

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