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Catalog Number: (10268-698)
Supplier: Bioss
Description: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.


Catalog Number: (10719-790)
Supplier: Abnova
Description: Mouse monoclonal antibody raised against partial recombinant ITGB1.


Catalog Number: (10094-570)
Supplier: Proteintech
Description: SNAI1, a member of SNAI1 family of protein, participates in the epithelial to mesenchymal transition(EMT) and formation and maintenance of embryonic mesoderm. The snail family share a common structural, that a highly conserved C-terminal region containing a zinc finger transcription factor. SNAI1 interacts with other corepressor, such as Ajuba, PRMT5 and SIN3a or HDAC1 and 2, to repress the target gene.


Catalog Number: (102239-870)
Supplier: Novus Biologicals
Description: SNTB1 Lysate (Adult Normal)


Catalog Number: (10107-308)
Supplier: Prosci
Description: SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.


Catalog Number: (102199-262)
Supplier: Novus Biologicals
Description: The CTRB1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to CTRB1. This antibody reacts with human. The CTRB1 Antibody has been validated for the following applications: Western Blot.


Catalog Number: (102190-216)
Supplier: Novus Biologicals
Description: The ATAT1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ATAT1. This antibody reacts with human. The ATAT1 Antibody has been validated for the following applications: Western Blot.


Catalog Number: (10370-778)
Supplier: Bioss
Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.


Catalog Number: (102711-514)
Supplier: Novus Biologicals
Description: The SETDB1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SETDB1. This antibody reacts with human. The SETDB1 Antibody has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Immunoprecipitation.


Catalog Number: (102151-306)
Supplier: Novus Biologicals
Description: SMAP1 Overexpression Lysate (Adult Normal)


Catalog Number: (10750-538)
Supplier: Prosci
Description: SCARB1 Antibody: Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus.


Catalog Number: (102209-858)
Supplier: Novus Biologicals
Description: The SATB2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SATB2. This antibody reacts with human, mouse, rat. The SATB2 Antibody has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, ELISA, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (10094-638)
Supplier: Proteintech
Description: SIAH1, also named as HUMSIAH, Siah-1a and Siah-1S(21kd), belongs to the SINA (Seven in absentia) family. SIAH1 is known to cause indirect degradation of beta-catenin through formation of a complex with Siah-interacting protein (SIP), Skp1 and Ebi. SIAH1 can form heterodimer or homodimer such as Siah-1*Siah-1(70 or 62kd), Siah-1*Siah-1S(42kd) and Siah-1S*Siah-1S(51-56kd). Importantly, results from in vitro soft agar assay demonstrated that Siah-1S displays a promotion effect on cells tumorigenicity.


Catalog Number: (89516-882)
Supplier: Abgent
Description: Polyclonal Antibody, Host: , Isotype: Rabbit Ig, Species Reactivity: Human, Gene ID: 27241, Target/Specificity: generated from rabbits immunized with a KLH conjugated synthetic peptide between 832-859 amino acids from the C-terminal region of human PTHB1.


Catalog Number: (102155-822)
Supplier: Novus Biologicals
Description: The SATB2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SATB2. This antibody reacts with human. The SATB2 Antibody has been validated for the following applications: Immunoprecipitation, Western Blot (Negative).


Catalog Number: (102151-290)
Supplier: Novus Biologicals
Description: SMAD1 Overexpression Lysate (Adult Normal)


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