You Searched For: Aluminium+oxide

Catalog Number: (10417-744)

Supplier: Bioss

Description: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.

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Catalog Number: (10256-202)

Supplier: Bioss

Description: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

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Supplier: Honeywell Research Chemicals

Description: For HPLC, liquid and gas chromatography, pesticide residue analysis, spectophotometry, organic synthesis and combinatorial chemistry.

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Catalog Number: (75932-906)

Supplier: Rockland Immunochemical

Description: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.

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Catalog Number: (76579-618)

Supplier: SLICE, INC.

Description: The wide-grip scraper works like an extension of your hand, offering a 12 cm (4.5”) surface of zirconium oxide blade to remove rust, paint, adhesive, or whatever else. With a comfortable soft-touch overlay and a finger-friendly® blade, the 10501’s handle is designed for continuous use and features blade-guard storage.

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Catalog Number: (75789-112)

Supplier: Prosci

Description: Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain.

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Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00149666 Soluble in water, methanol, ethanol, acetic acid, acetic anhydride, and acetone

SDS Certificates

Supplier: Corning

Description: Corning® Gosselin™ offers a wide range of disposable sampling tools including Pipettes.

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Catalog Number: (102514-618)

Supplier: Adipogen

Description: GPX1 is an antioxidant enzyme that is down-regulated in cancer cells. Protects the hemoglobin in erythrocytes from oxidative breakdown. Its main role is the prevention of cancer initiation by ROS-mediated DNA damage.

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Catalog Number: (76079-630)

Supplier: Bioss

Description: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

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Supplier: Steris

Description: Cage-Klenz® 180 Detergent is a liquid, phosphate-free detergent for use in high pressure spray animal cage washing equipment. It is formulated with corrosion inhibitors for enhanced materials compatibility.

SDS Certificates

Catalog Number: (76482-312)

Supplier: AAT BIOQUEST INC

Description: This fluorogenic coumarin ether is widely used for monitoring P450 activities in cell extracts and solutions.

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Catalog Number: (76083-004)

Supplier: Bioss

Description: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:3202973, PubMed:3597401). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (By similarity).

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Catalog Number: (77191-802)

Supplier: AMBEED, INC

Description: 2-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, Purity: 98%, CAS Number: 873798-09-5, Appearance: Form: Crystal - Powder/Colour: White - Very pale yellow - Yellow, Storage: Inert atmosphere, 2-8 C, Size: 1g

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Catalog Number: (76100-064)

Supplier: Bioss

Description: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

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Supplier: Strem Chemicals Inc

Description: Phosphine, Phosphine, Water Soluble