You Searched For: INDUSTRIAL DEVELOPEMENT

Catalog Number: (10450-562)

Supplier: Bioss

Description: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity; Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities; Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Supplier: Adipogen

Description: Naturally occurring carnitine derivative formed by carnitine acetyltransferase during beta-oxidation of uneven chain fatty acids, with high affinity for muscular carnitine transferase. Increases cellular carnitine content, allowing free fatty acid transport into the mitochondria. Stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity. Important for mitochondrial metabolism and energy regulation. Regulates the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. Selectively inhibits in vitro and ex vivo platelet-activating factor (PAF) synthesis from human neutrophils. Antioxidant. Shows free radical scavenging activity. Decreases the expression of inducible nitric oxide synthase (iNOS/NOS II) and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells. Shows beneficial cardiovascular effects. Improves body weight, food intake, adiposity and insulin resistance in Type 2 diabetes. Stimulates endothelial nitric oxide (eNOS/NOS III) and increased NO production, via AMPK/Src-mediated signaling that leads to activation of PI3 kinase and Akt.

Catalog Number: (10232-308)

Supplier: Bioss

Description: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

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Catalog Number: (89407-734)

Supplier: Hardy Diagnostics

Description: Used as a sealant to create an anaerobic environment for biochemical tests such as decarboxylase; and oxidation and fermentation reactions.

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Supplier: Adipogen

Description: Herbicide. Mode of action is similar to herbicides that inhibit the protoporphyrinogen oxidase (Protox) enzyme in susceptible plant species that leads to an uncontrolled nonenzymatic oxidation of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto) and successive necrosis.

Catalog Number: (TCH0902-001G)

Supplier: TCI America

Description: [for Source of Alkyl Radical] CAS Number: 49762-08-5 MDL Number: MFCD00077793 Molecular Formula: C4H5NOS2 Molecular Weight: 147.21 Purity/Analysis Method: <gt/>98.0% (T) Form: Crystal Melting point (°C): 96

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Catalog Number: (89416-212)

Supplier: Prosci

Description: TIGAR Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.

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Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00049554

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Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00014231

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Supplier: Thermo Scientific Chemicals

Description: Applications: Hydrogenation, isomerization, carbonylation, oxidation, C-C bond formation

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Supplier: Veltek Associates

Description: Sterile water for chemical formulation, cleaning, and rinsing.

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Catalog Number: (76109-898)

Supplier: Bioss

Description: Members of the class-III pyridoxal-phosphate-dependent aminotransferase family, such as AGXT2, catalyze the conversion of glyoxylate to glycine using L-alanine as the amino donor. AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis. AGXT2L2 (alanine-glyoxylate aminotransferase 2-like 2) is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2.

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Catalog Number: (TCB5240-1G)

Supplier: TCI America

Description: Bis[2-[(oxo)diphenylphosphino]phenyl] Ether, Purity: >97.0%(HPLC), CAS Number: 808142-23-6, Molecular Formula: C36H28O3P2, Molecular Weight: 570.56, Synonyms: DPEPO, Size: 1G

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Catalog Number: (10347-942)

Supplier: Bioss

Description: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.

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Supplier: GeminiBio

Description: GeminiBio’s Water for Irrigation (WFIr) Quality Water (USP Grade) is a hypotonic, sterile non-pyrogenic irrigating water produced by our proprietary water purification system. Manufactured and tested in compliance with the USP monograph for bulk packaged water for irrigation, GemPure™ Select Water for Irrigation (WFIr) Quality Water (USP Grade) is ideal for use in the manufacture and testing of medical devices, and applications where Water For Injection is not required.

Supplier: Thermo Scientific Chemicals

Description: 99.9% (REO).Powder,WARNING: Irritates skin, eye, lungs; affects blood clotting,1g,5g.

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