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Catalog Number: (10271-206)
Supplier: Bioss
Description: CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.


Catalog Number: (71003-690)
Supplier: Decon Labs
Description: AquaPur Purified Water has been tested to meet USP/EP specifications for purified water. Packaged in convenient point of use packaging for laboratory or production applications requiring purified water. The product is filtered to 0.2 µm and is guaranteed to meet specifications through expiration date.

Supplier: Adipogen
Description: Pro-inflammatory peptide, acting through G-protein-coupled receptors. Endogenous bradykinin receptor agonist that displays selectivity for B2 over B1 receptors. Endogenously formed following pathophysiological stimuli such as inflammation, tissue damage or anoxia. Activator of endothelial nitric oxide synthase (eNOS; NOS III). Reduces blood pressure by inducing the release of prostacyclin, nitric oxide and endothelium-derived hyperpolarizing factor. Plays an important role in the regulation of fluid and electrolyte balance, non-vascular smooth muscle contraction, vasodilation and capillary permeability.

Catalog Number: (10375-034)
Supplier: Bioss
Description: Mammalian PNK catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. It plays an important function in DNA repair following ionizing radiation or oxidative damage.PNK has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.


Catalog Number: (76322-110)
Supplier: Alconox


Catalog Number: (76100-524)
Supplier: Bioss
Description: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.


Supplier: Adipogen
Description: A Hypervalent iodine reagent for oxidation reactions.

Catalog Number: (75791-124)
Supplier: Prosci
Description: Ferritin is a large, iron-storage heteropolymeric protein,which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin has oligomer of 24 subunits and two types of subunits including light chain(FTL) and heavy chain. Ferritin can remove Fe (Ⅱ) from solution in the presence of oxygen and is very important for iron homeostasis. Iron is absorbed in the ferrous form and deposited as ferric hydroxides after oxidation. Iron is first oxidized to the ferric state for storage as ferric oxyhdroxide whithin the protein shell of ferritin. Thus, ferritin removes excess iron from the cell sap where it could otherwise participate in peroxidation mechanisms. Ferritin also plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney.


Catalog Number: (75856-400)
Supplier: MP Biomedicals
Description: DNase-free water (DES).

SDS


Supplier: Thermo Scientific Chemicals
Description: Hydrosilation, isomerization, carbonylation, oxidation, and C-C bond formation
Catalog Number: (10083-060)
Supplier: Proteintech
Description: ARG2(Arginase-2, mitochondrial) is also named as kidney-type arginase, non-hepatic arginase and belongs to the arginase family. It may play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.


Catalog Number: (10452-866)
Supplier: Bioss
Description: Uricase catalyzes the oxidation of uric acid to 5 hydroxyisourate which spontaneously decomposes to form allantoin.


Catalog Number: (10286-456)
Supplier: Bioss
Description: ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.


Catalog Number: (10407-592)
Supplier: Bioss
Description: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.


Supplier: GeminiBio
Description: GemPure™ Plus Water for Injection (WFI) Quality Water (USP/EP/JP Grade) optimizes your upstream and downstream bioprocess workflows and productivity from development to commercial production and meets specifications of monographs for the United States Pharmacopeia (USP), European Pharmacopeia (EP), and Japanese Pharmacopeia (JP).

Supplier: Anaspec Inc
Description: Proteins interactions with reactive oxygen agents may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages and oxidation of the protein backbone resulting in protein fragmentation. Oxidation targets for Aß(1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aß in senile plaque of Alzheimer’s disease with Aß (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of Aß and free radical damage.
Sequence: DAEFRHDSGYEVHHQK
Molecular Weight: 1955 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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