You Searched For: HPLC+Solvents

Description: Stim II antibody functions as a calcium sensor in the endoplasmic reticulum via its EF-hand domain. After depletion of Ca+2, it is thought to translocate from the endoplasmic reticulum to the plasma membrane to activate the calicum release-activated channel subunit. It may inhibit STIM1-mediated calcium influx. Anti-Stim II antibody is ideal for investigators interested in Signal Transduction research.

Catalog Number: 75935-406

Supplier: Rockland Immunochemical

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Catalog Number: RL20041350100

Supplier: Rockland Immunochemical

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Description: ROS1 rearrangements occur infrequently in lung ACA, however given the frequency of lung cancer in the population, ROS1-rearranged tumors represent a significant number of cancer patients. ROS1 gene rearrangements are reported in 1 to 2% of lung adenocarcinomas (ACA) and are associated with response to the multitargeted tyrosine kinase inhibitor, crizotinib. ROS IHC can be readily incorporated into the diagnostic surgical pathology workup of lung adenocarcinoma, with results confirmed by FISH as needed.

Catalog Number: 76634-886

Supplier: Diagnostic Biosystems

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Description: F(Ab)2 Anti-Chicken Igg [Handl] (Rabbit) Antibody Texas Red* Conjugated - 703-409-002 F(Ab)2 Chicken Igg (Handl) Antibody Texas Red* Conjugated 500Ul

Catalog Number: RL703-409-002

Supplier: Rockland Immunochemical

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Description: In muscle tissue, collagen serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. This collagen appears to be largely restricted to structures identifiable as basement membranes. In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. The extent to which type VII and VIII collagens are distributed is not known.

Catalog Number: 76262-810

Supplier: Rockland Immunochemical

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Description: Secondary Rabbit Anti-IgG F(c) Reacts with Human

Catalog Number: RL609-4003

Supplier: Rockland Immunochemical

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Description: This product has been assayed against 1.0 µg of Cyanine conjugated Sheep IgG in a standard capture ELISA using ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])

Catalog Number: RL600-603-209

Supplier: Rockland Immunochemical

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Description: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Catalog Number: 10802-258

Supplier: Rockland Immunochemical

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Description: Donkey anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, chicken, goat, guinea pig, hamster, horse, human, mouse, rat or sheep

Catalog Number: 76040-252

Supplier: Tonbo Biosciences

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Description: Goat Anti-Red Fluorecent Protein Antibody

Catalog Number: 76234-960

Supplier: Rockland Immunochemical

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Description: DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.

Catalog Number: 10800-982

Supplier: Rockland Immunochemical

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Description: EMX1 is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and it participates in the development of olfactory neurons. EMX1 is specifically expressed in the developing telencephalic cortex expression, where epxression is restricted to pyramidal neurons. EMX1 is a reliable marker of pyramidal neurons and pyramidal cell lineage. EMX1 has been shown to be one of the downstream target genes for Gli-Kruppel family member 3 (Gli3) transcription factor, which is a part of the Sonic hedgehog-Patched-Gli signaling pathway important in endocrine signaling.

Catalog Number: 10802-090

Supplier: Rockland Immunochemical

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Description: Produced through a multi-stage process that includes delipidation, salt fractionation, ion-exchange chromatography, gel filtration, and affinity chromatography. No contaminating proteins are observed when assayed at a protein concentration of 20mg/mL against anti-whole serum or anti-fragment specific antisera. All immunoglobulin fragments are prepared from highly purified, whole molecules subject to enzymatic digestion.

Catalog Number: RL010-0641

Supplier: Rockland Immunochemical

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Description: Anti-Mouse IgG2b secondary antibody is suitable for ELISA.

Catalog Number: RL610-155-042

Supplier: Rockland Immunochemical

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Description: STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. STAT2 pS734 antibody is ideal for researchers focused in cancer and transcripton factor research.

Catalog Number: 75932-188

Supplier: Rockland Immunochemical

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Description: Host: Mouse, Isotype: IgG1

Catalog Number: 89156-762

Supplier: Enzo Life Sciences

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