You Searched For: Hach

Supplier: Tonbo Biosciences

Description: The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte “rolling” on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.

Catalog Number: (10802-426)

Supplier: Rockland Immunochemical

Description: The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kB by decreasing the activation of IKK.

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Catalog Number: (RL210-401-B51)

Supplier: Rockland Immunochemical

Description: This purified antibody has been tested for use in neutralizations, ELISA and western blotting. Reactivity is also expected in radioimmunoassay.

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Catalog Number: (10801-044)

Supplier: Rockland Immunochemical

Description: The mammalian A-type cyclin family consists of 2 members, cyclin A1 (CCNA1) and cyclin A2 (CCNA2). Human cyclin A gene is assigned to 4q26-q27. Cyclin A protein is synthesized and localized into the nucleus at the onset of S phase in nontransformed mammalian fibroblasts. This antibody is suitable for researchers interested in cancer research, apoptosis, autoimmune disease, neurodegenerative disease, cardiovascular disease, MAP Kinase Signaling, AKT Signaling, Inflammatory Signaling, and Cell Cycle research.

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Catalog Number: (89153-456)

Supplier: Enzo Life Sciences

Description: Host: Mouse, Isotype: IgG1

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Catalog Number: (RL100-401-156)

Supplier: Rockland Immunochemical

Description: Anti-Cyclin-E antibody is suitable for the detection by immunoblot, ELISA and IP. Researchers should determine optimal titers for applications that are not stated below. Antiserum will specifically react with a 45 kDa Cyclin E Protein from human tissue.

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Catalog Number: (76285-064)

Supplier: Enzo Life Sciences

Description: Recombinant monclonal antibody (Rat IgG2bκ).

Recommended Applications: ELISA, WB

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Catalog Number: (RL20043750100)

Supplier: Rockland Immunochemical

Description: Polyclonal antibody, Host:rabbit, Species reactivity:Enterobacter cloacae, isotype:IgG, Label:Peroxidase (Horseradish), Immunogen:Penicillinase [Enterobacter cloacae], Application:Western Blot

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Catalog Number: (75932-986)

Supplier: Rockland Immunochemical

Description: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.

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Catalog Number: (RL609-4204)

Supplier: Rockland Immunochemical

Description: Secondary Rabbit Anti-IgG F(ab')2 Reacts with Human

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Catalog Number: (10051-934)

Supplier: Enzo Life Sciences

Description: Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing GPCR family, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 receptors signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity and modulate cellular potassium and calcium ion channel conductance. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.

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Supplier: Rockland Immunochemical

Description: The emission spectra for this ATTO conjugate matches the principle output wavelengths of most common fluorescence instrumentation.

Catalog Number: (89155-450)

Supplier: Enzo Life Sciences

Description: HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.

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Catalog Number: (RL200-301-F82)

Supplier: Rockland Immunochemical

Description: Anti-KCNQ1 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~75kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

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Catalog Number: (10150-610)

Supplier: Immunoreagents

Description: ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualized, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.

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Catalog Number: (RL200-103-189S)

Supplier: Rockland Immunochemical

Description: Anti-Invertase has been assayed against 1.0 µg of Invertase (Candida) in a standard capture ELISA using ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])

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