You Searched For: Antibodies

Catalog Number: (75929-410)

Supplier: Rockland Immunochemical

Description: The potassium channel, subfamily K, member 1 (KCNK1), is member of the superfamily of potassium channel proteins containing two pore-forming P domains (1,2). KCNK1 is a ubiquitous human weakly inward rectifying K+ channel that is widely expressed in human tissues, and particularly abundant in brain and heart (1). Both KCNK1 and the related protein KCNK2 contribute significantly to the passive conductance of hippocampal astrocytes (3).

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Catalog Number: (ABCA_AB197321-100U)

Supplier: ABCAM INC.

Description: Anti-RNF183 Rabbit Polyclonal Antibody

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Catalog Number: (ABCA_AB300475-100U)

Supplier: ABCAM INC.

Description: Anti-GPNMB Rabbit Monoclonal Antibody [clone: EPR18226-147] (Alexa Fluor® 647)

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Catalog Number: (ABCA_AB117273-250U)

Supplier: ABCAM INC.

Description: Anti-GNAO1 Rabbit Polyclonal Antibody

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Catalog Number: (75929-234)

Supplier: Rockland Immunochemical

Description: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Catalog Number: (ABCA_AB125195-100U)

Supplier: ABCAM INC.

Description: Anti-Cdc6 Rabbit Polyclonal Antibody

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Catalog Number: (ABCA_AB113488-100U)

Supplier: ABCAM INC.

Description: Anti-15-LOX-2 Rabbit Polyclonal Antibody

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Catalog Number: (ABCA_AB93785-100UL)

Supplier: ABCAM INC.

Description: Anti-NFIL3 Rabbit Polyclonal Antibody

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Catalog Number: (ABCA_AB63333-100UG)

Supplier: ABCAM INC.

Description: Anti-Transferrin Receptor Rat Monoclonal Antibody [clone: R17217.1.4] (Biotin)

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Catalog Number: (10799-970)

Supplier: Rockland Immunochemical

Description: Anti-Alpha Internexin antibody recognizes alpha-internexin which is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits. Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration. The use of Antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder. The antibody was also used to confirm the presence of circulating auto-Antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals. Anti-Alpha Internexin antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

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Catalog Number: (ABCA_AB205813-100U)

Supplier: ABCAM INC.

Description: Anti-M6PR (cation independent) Mouse Monoclonal Antibody [clone: 2G11] (Alexa Fluor® 647)

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Catalog Number: (ABCA_AB176115-100U)

Supplier: ABCAM INC.

Description: Anti-EZH1 Rabbit Polyclonal Antibody

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Catalog Number: (ABCA_AB6788-1MG)

Supplier: ABCAM INC.

Description: Anti-IgG Goat Polyclonal Antibody [clone: ] (Biotin)

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Supplier: ABCAM INC.

Description: Anti-Cystatin C Rabbit Monoclonal Antibody [clone: EPR4413]

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Supplier: Enzo Life Sciences

Description: The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Catalog Number: (ABCA_AB310519-100U)

Supplier: ABCAM INC.

Description: Anti-Ubiquitin Rabbit Monoclonal Antibody [clone: EPR8830] (Alexa Fluor® 594)

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