7-Aminoactinomycin D (7-AAD) ≥97% (by HPLC)

Supplier: ALADDIN SCIENTIFIC CORPORATION
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A131295-1MG A131295-25MG A131295-5MG
ALA131295-1MGEA 112.01 USD
ALA131295-1MG ALA131295-25MG ALA131295-5MG
7-Aminoactinomycin D (7-AAD) ≥97% (by HPLC)
7-Aminoactinomycin D (7-AAD)

7-Aminoactinomycin D ,an analog of the antibiotic actinomycin D ,is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies. As a fluorescent DNA dye, 7-AAD is able to intercalate DNA via binding to the GC regions. When used in flow cytometery, 7-AAD can be used to discriminate between live cells as well as early and late apoptosis. Additionally, 7-AAD can also be combined with other staining procedures for analysis of intracellular and cell surface antigens enabling multiparametric analysis. When utilizing 7-AAD with flow cytometery, early and late apoptosis can be studied by varying the concentration of 7-AAD. During apoptosis, the cellular plasma membrane is altered progressively, which allows the cell membrane to become permeable to 7-AAD. 7-AAD staining can also be adapted to include staining with other dyes for intracellular and cell surface antigens. 7-Aminoactinomycin D is an inhibitor of DNA Polymerase and RNA PolymeraseA fluorescent DNA dye for apoptosis and flow cytomtery studies.

Formula: C₆₂H₈₇N₁₃O₁₆
Melting Pt: 252-253°C
Storage Temperature: Ambient
MDL Number: MFCD00077295
CAS Number: 7240-37-1

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