Calbiochem® MG-132
Supplier: EMD MILLIPORE (BIOSCIENCES)
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474790-5MG
474790-1MG
80053-196EA
251.3
USD
80053-196
80053-194
Calbiochem® MG-132
Proteins and Peptides
A potent, reversible, and cell-permeable proteasome inhibitor (Ki=4nM)
Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-[kappa]B activation (IC50=3µM).
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