(R)-Roscovitine, Calbiochem®

Supplier: EMD MILLIPORE (BIOSCIENCES)

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557360-5MG 557360-1MG

80054-316EA 368.52 USD

80054-316 80054-314

(R)-Roscovitine, Calbiochem®

(R)-Roscovitine

A potent and selective inhibitor of cyclin-dependent kinases (cdks) that exhibits about ten-fold greater efficacy towards p34cdc2 and p33cdk2, and twenty-fold greater efficacy towards p33cdk5 relative to olomoucine (80053-494, -496)

Inhibits p34cdc2/cyclin B (IC50=650nM), p33cdk2/cyclin A (IC50=700nM), p33cdk2/cyclin E (IC50=200nM), and p33cdk5/p35 (IC50=200nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases, including ERK1 and ERK2 (IC50=34µM and 14µM respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100µM, including p34cdk4/cyclin D1 and p40cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.

Formula: C₁₉H₂₆N₆O

MDL Number: MFCD02266401
CAS Number: 186692-46-6

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