Genistein, Sigma-Aldrich®
Supplier: EMD MILLIPORE (BIOSCIENCES)Total Ratings: 0
Avg. Ratings: 0.0 out of 5
Inhibits protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50=2.6µM)
The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50>350µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
Formula:
C₁₅H₁₀O₅ MW: 270.24 g/mol |
MDL Number:
MFCD00016952 CAS Number: 446-72-0 |
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