Anti-Mismatch Repair Protein 2, MSH2 Mouse Monoclonal Antibody [clone: DBM15.82]

Supplier: Diagnostic Biosystems
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MOB585-01-RUO MOB585-05 MOB585
76634-192EA 97 USD
76634-192 76634-194 76634-196
Anti-Mismatch Repair Protein 2, MSH2 Mouse Monoclonal Antibody [clone: DBM15.82]
Antibodies
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
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