Human Recombinant sTNF Receptor Type I (from E. coli)

Supplier: PEPROTECH INC.
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AF-310-07-5UG AF-310-07-20UG AF-310-07-100UG AF-310-07-250UG AF-310-07-500UG AF-310-07-1MG
76303-650EA 158.05 USD
76303-650 76303-652 76303-654 76303-656 76303-658 76303-660
Human Recombinant sTNF Receptor Type I (from E. coli)
Proteins and Peptides

TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-kappaB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein.


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