L(+)-Histidine 99.0-101.0% (by perchloric acid titration), EMPROVE® EXPERT Ph. Eur., USP, JP, SAFC®
Supplier: EMD MILLIPORE - PCS - GPS
Ratings:
(No Reviews)
Total Ratings: 0
Avg. Ratings: 0.0 out of 5
1.04352.1000
1.04352.9010
EM1.04352.1000CS
25419.73
USD
EM1.04352.1000
EM1.04352.9010
L(+)-Histidine 99.0-101.0% (by perchloric acid titration), EMPROVE® EXPERT Ph. Eur., USP, JP, SAFC®
L(+)-Histidine
Formula:
C₆H₉N₃O₂ Melting Pt: 272...273 °C Dec. Density: 0.43 g/cm³ Storage Temperature: Ambient |
MDL Number:
MFCD00064315 CAS Number: 71-00-1 EINECS: 200-745-3 |
Specification Test Results
Assay (Acidimetric, Calculated on Dried Substance) | 98.5 - 101.0% |
Assay (Perchloric Acid Titration, Calculated on Dried Substance) | 99.0 - 101.0% |
Identity (IR-spectrum) | Passes Test |
Appearance | White to Almost White Fine-Crystalline Powder or Colorless Crystals |
Appearance of Solution (50 g/l; Water) | Clear and not More Intense in Color than Reference Solution BY₇ |
Appearance of Solution (20 g/l, Water) | Clear and Colorless |
Specific Rotation (α 20/D, 110 g/l, Hydrochloric Acid 120 g/l, Calculated on Dried Substance) | +11.4 to +12.4 |
Specific Rotation (α 25/D, 110 g/l, Hydrochloric Acid 6 mol/l, Calculated on Dried Substance) | +12.6 to +14.0 |
Specific Rotation (α 20/D, 110 g/l, Hydrochloric Acid 6 mol/l, Calculated on Dried Substance) | +11.8 to +12.8° |
pH (20 g/l, CO₂-Free Water) | 7.0 - 8.5 |
Chloride (Cl) | ≤200 ppm |
Sulfate (SO₄) | ≤200 ppm |
Heavy Metals (as Pb) | ≤10 ppm |
Cu (Copper) | ≤25 ppm |
Fe (Iron) | ≤10 ppm |
Fe (Iron) (ICP) | ≤10 ppm |
Mn (Manganese) | ≤25 ppm |
Zn (Zinc) | ≤130 ppm |
Related Compounds, total (TLC) | ≤0.5% |
Related Substances (TLC) | Passes Test |
Ninhydrin-Positive Substances (LC) (Any Ninhydrin-Positive Impurity) | ≤0.2% |
Ninhydrin-Positive Substances (LC) (Ammonium (570 nm)) | ≤0.02% |
Ninhydrin-Positive Substances (LC) (Total Impurities) | ≤0.5% |
Residual Solvents (ICH (Q3C)) | Excluded by Manufacturing Process |
Sulfated ash (600 °C) | ≤0.1% |
Loss on Drying (105 °C; 3 h) | ≤0.2% |
Bacterial Endotoxins | <2.0 |
Microbiological Test (Total Aerobic Microbial Count (TAMC)) | ≤10² |
Microbiological Test (Total Yeast and Mould Count (TYMC)) | ≤10² |
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*). | |
Corresponds to Ph. Eur., JP, USP |
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