Calbiochem® Human Angiotensin II

Supplier: EMD MILLIPORE (BIOSCIENCES)

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05-23-0101-5MG 05-23-0101-1MG

80603-298EA 108.98 USD

80603-298 80011-516

Calbiochem® Human Angiotensin II

Proteins and Peptides

Angiotensin II plays an important role in the regulation of blood pressure.

Peptide sequence: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Angiotensin II stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K⁺ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125^FAK and a cytosolic 115 to 120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60^c-src as well as ERK1/2, JNK, and p38MAP Kinase in vascular smooth muscle cells.

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