CAY10657 ≥98%

Supplier: CAYMAN CHEMICAL COMPANY, INC.

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11140-5 11140-10

76292-986EA 200.4 USD

76292-986 76292-988

CAY10657 ≥98%

CAY10657

The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules. Under resting conditions NF-κB dimers are retained in the cytoplasm by a member of the IKB family of inhibitory proteins. Upon activation by cytokines or other stimuli, IKK phosphorylates IKB, initiating a signaling cascade to activate gene transcription. CAY10657 is a thiophenecarboximide derivative proposed to inhibit IKK2. Currently, there are no published reports of its biological activity. However, inhibition of NF-κB activation is likely to be of broad utility in the treatment of inflammatory diseases and cancer.

Formula: C₁₇H₂₀N₄O₃S
MW: 360.4 g/mol
Storage Temperature: Freezer

CAS Number: 494772-86-0

https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=797efc935324a76d8befe959318e7ac70397d221&vid=797efc935324a76d8befe959318e7ac70397d221&prid=web&clid=SAPDAM

https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=6d49712a091fb7567a8ea045a63f361467db4de6&vid=6d49712a091fb7567a8ea045a63f361467db4de6&prid=web&clid=SAPDAM

https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=000911d2630ac779732f6131b13b29fc6fd8557e&vid=000911d2630ac779732f6131b13b29fc6fd8557e&prid=web&clid=SAPDAM

Specification Test Results

Formulation	A crystalline solid
Purity	≥98%
Stability	≥ 2 years

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