Human Recombinant GDF-15/MIC-1 (from CHO Cells)

Supplier: PEPROTECH INC.
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120-28C-5UG 120-28C-20UG 120-28C-100UG 120-28C-250UG 120-28C-500UG 120-28C-1MG
76077-296EA 132.81 USD
76077-296 76077-298 76077-300 76077-302 76077-304 76077-306
Human Recombinant GDF-15/MIC-1 (from CHO Cells)
Proteins and Peptides

GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.

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