Human Recombinant ANGPTL-7 (from Hi-5 Insect cells)

Supplier: PEPROTECH INC.
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130-22-5UG 130-22-20UG 130-22-100UG 130-22-250UG 130-22-500UG 130-22-1MG
75999-452EA 135.76 USD
75999-452 75999-454 75999-456 75999-458 75999-460 75999-462
Human Recombinant ANGPTL-7 (from Hi-5 Insect cells)
Proteins and Peptides

Angiopoietin-like 7 (ANGPTL-7), or Cornea-Derived Transcript 6 (CDT6), is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. While ANGPTL-7 shares the structural features of the angiopoietin family, it plays a critical role in blocking the vascular endothelial Tie2 receptor to which other family members bind. Through the blocking of the Tie2 receptor, ANGPTL-7 does not act as a “true” angiopoietin, but rather as a morphogen that contributes to the avascularity and transparency of the cornea during both embryo and adult development. Human ANGPTL-7 is expressed at high levels in the avascular corneal stromal layer, a site of pathological angiogenesis normally devoid of blood vessels, suggesting that the protein acts as a negative regulator of angiogenesis in a manner similar to that of angiopoietin-1 and angiopoietin-2. In mouse xenograft models, ANGPTL-7overexpression has been shown to lead to increased extracellular matrix components typical of a mature corneal stromal layer, as well as the reduction of tumor growth and aberrant blood vessel formation. Overexpression in human melanoma models shows a contradictory, up-regulation of endostatin, an endogenous angiostatic factor, in comparison to the down-regulation observed in mouse models. Recombinant Human ANGPTL-7 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 40- 50 kDa under reduced conditions, and contains 328 amino acid residues including a C-terminal His-tag. The calculated molecular weight of Recombinant Human ANGPTL-7 is 38.2 kDa.

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