Bovine Aprotinin (from Lung), MP Biomedicals
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Aprotinin is found in bovine lymph nodes, lung, parotid gland, spleen, liver, pancreas, seminal vesicles, thyroid gland, kidney, mucous membranes of the trachea and esophagus, ovaries, heart, posterior pituitary and cartilage. It is a serine protease inhibitor which is reactive against trypsin, chymotrypsin, plasmatic and glandular kininogenases, plasmin, kallkrein, urokinase, clotting factor XIIa, protein C, proteinases of the complement system, leukocyte and tissue proteinases. It does not inhibit thrombin. Aprotinin works by blocking the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH > 10 or < 3.
- Specific Activity : ≥3 TIU/mg
- Key Applications : Inhibitor Stain
- Application Areas : Molecular biology
- Product Type : Biochemicals
- Biochemical Category : Pharmaceuticals
- Extinction Coefficient (E1%) : (280 nm) = 8.3 (water)
- UV/Visible Absorbance : λ max (water) - 277 ± 5 nm
- Presentation : White Powder
- White Powder : 10.5
- pH : 5.0 - 7.0 (1% aq soln)
- Water Content : ≤6%
- Solubility : Soluble in water (10 mg/mL - completely soluble) and in aqueous buffers of low ionic strengths.
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