Human Recombinant GDNF (from E. coli)

Supplier: PEPROTECH INC.
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AF-450-10-2UG AF-450-10-10UG AF-450-10-50UG AF-450-10-100UG AF-450-10-250UG AF-450-10-500UG AF-450-10-1MG
10781-820EA 180.86 USD
10781-820 10781-822 10781-824 10781-826 10781-828 10781-830 10781-832
Human Recombinant GDNF (from E. coli)
Proteins and Peptides

GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa.


  • Animal-free


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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