Human Recombinant Persephin* (from E. coli)

Supplier: PEPROTECH INC.
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450-12-5UG 450-12-20UG 450-12-100UG 450-12-250UG 450-12-500UG 450-12-1MG
10781-244EA 132.81 USD
10781-244 10781-246 10781-248 10781-250 10781-252 10781-254
Human Recombinant Persephin* (from E. coli)
Proteins and Peptides

Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR α (α1-α4) receptors. The GFRα4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons. Recombinant Human Persephin is a disulfide-linked homodimer, composed of two 10.4 kDa polypeptide chains (194 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 64) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine knot configuration.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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