Human Recombinant Neurturin (from E. coli)

Supplier: PEPROTECH INC.

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10781-232EA 143.88 USD

10781-232 10781-234 10781-236 10781-238 10781-240 10781-242

Human Recombinant Neurturin (from E. coli)

Proteins and Peptides

Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, artemin, and persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. The functional form of human neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine knot configuration.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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