Human Recombinant GDNF (from E. coli)

Supplier: PEPROTECH INC.
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

450-10-2UG 450-10-10UG 450-10-100UG 450-10-250UG 450-10-500UG 450-10-1MG
10781-218EA 144.78 USD
10781-218 10781-220 10781-222 10781-224 10781-226 10781-228 10781-230
Human Recombinant GDNF (from E. coli)
Proteins and Peptides

GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

Order Now


Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR