Human Recombinant MANF (from E. coli)

Supplier: PEPROTECH INC.

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10781-206EA 132.81 USD

10781-206 10781-208 10781-210 10781-212 10781-214 10781-216

Human Recombinant MANF (from E. coli)

Proteins and Peptides

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain an N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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