Human Recombinant MMP-1 (from E. coli)

Supplier: PEPROTECH INC.

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420-01-2UG 420-01-10UG 420-01-100UG 420-01-250UG 420-01-500UG 420-01-1MG

10781-104EA 132.81 USD

10781-104 10781-106 10781-108 10781-110 10781-112 10781-114

Human Recombinant MMP-1 (from E. coli)

Proteins and Peptides

Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant Human MMP-1 is a 42.7 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain, which is involved in substrate specificity, and in binding TIMP-1.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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