Mouse Recombinant GDNF (from E. coli)

Supplier: PEPROTECH INC.
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AF-450-44-10UG AF-450-44-100UG AF-450-44-250UG AF-450-44-500UG AF-450-44-1MG
10771-848EA 412.7 USD
10771-848 10771-850 10771-852 10771-854 10771-856
Mouse Recombinant GDNF (from E. coli)
Proteins and Peptides

GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.


  • Animal-free


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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