Mouse Recombinant sRANK (from E. coli)

Supplier: PEPROTECH INC.
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

315-11-2UG 315-11-10UG 315-11-50UG 315-11-100UG 315-11-250UG 315-11-500UG 315-11-1MG
10770-912EA 143.88 USD
10770-912 10770-914 10770-916 10770-918 10770-920 10770-922 10770-924
Mouse Recombinant sRANK (from E. coli)
Proteins and Peptides

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Murine sRANK Ligand is a 19.4 kDa polypeptide comprising the TNF-homologous region of RANKL (174 amino acid residues).


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

Order Now


Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR