Toluene-α-sulfonyl fluoride, white to off white needle crystals
Supplier: TestTotal Ratings: 0
Avg. Ratings: 0.0 out of 5
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Danger
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Synonyms:
PMSF, Phenylmethanesulphonyl fluoride, Phenylmethylsulphonyl fluoride, α-Toluenesulfonyl fluoride, α-Toluenesulphonyl fluoride, Phenylmethanesulfonyl fluoride, Phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Inhibits mammalian acetyl cholinesterase, but not those from fish sources.
- Presentation: White to off white needle crystals
- Causes sulfonylation of the active-site serine residue
- A less toxic substitute for the extremely toxic diisopropylfluorophosphate
Phenylmethylsulfonyl fluoride inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase.
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.
Soluble in methanol and ethanol
Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Causes sulfonylation of the active-site serine residue. A less toxic substitute for the extremely toxic diisopropylfluorophosphate. Inhibits mammalian acetyl cholinesterase, but not those from fish sources. Recommended concentration is 15 to 175 ug/mL.
Formula:
C₇H₇FO₂S MW: 174.2 g/mol Melting Pt: 89…99 °C Storage Temperature: Refrigerator |
MDL Number:
MFCD00007424 CAS Number: 329-98-6 UN: 2928 ADR: 6.1,II |
Specification Test Results
Identity Test | Passes |
FTIR | Conforms to Standard |
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