Paclitaxel ≥98%, powder

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0219353201 0219353205 0219353225

IC19353201EA 62.41 USD

IC19353201 IC19353205 IC19353225 IC0219353280

Paclitaxel ≥98%, powder

Paclitaxel

Soluble in methanol (50 mg/mL - clear, colorless solution), DMSO (50 mg/mL - clear, colorless solution), chloroform and ethanol. DMSO solutions can be stored aliquoted and frozen at -20 °C for several months. Paclitaxel undergoes transesterification in methanol, and it hydrolyzes in aqueous solutions; Hardly soluble in water.

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Formula: C₄₇H₅₁NO₁₄
MW: 853.91 g/mol

MDL Number: MFCD00869953
CAS Number: 33069-62-4

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