Trichloroacetic acid (TCA) ≥99%, powder
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Trichloroacetic acid is used in protein precipitation; has been used to determine protein concentration by quantitative precipitation.
It is also Used as a decalcifier and fixative in microscopy. A protocol for the precipitation of nucleic acids can be found in molecular cloning. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit. In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen. On the guinea pig trichloroacetic acid was observed to be a mild alergen on the skin.
Poison/deleterious substance code: 2 to 58
Chloride= ≤0,002%
Soluble in water(10% aq soln) - clear, colorless solution; very soluble in ethanol or ether. Decomposed by heating with caustic alkalies into chloroform and alkali carbonate. Long term storage of aqueous solutions of less than 30% strength is not recommended. Decomposition products are chloroform, hydrochloric acid, carbon dioxide and carbon monoxide.
Trichloroacetic acid is used in protein precipitation; has been used to determine protein concentration by quantitative precipitation. It is also Used as a decalcifier and fixative in microscopy. A protocol for the precipitation of nucleic acids can be found in Molecular Cloning. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit. In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen. On the guinea pig trichloroacetic acid was observed to be a mild alergen on the skin.
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Formula:
Cl₃CCOOH |
MDL Number:
MFCD00004177 CAS Number: 76-03-9 |
Specification Test Results
| Form | Powder |
| Storage | Store at Room Temperature(15-30 °C), desiccated. |
| Assay | ≥99% |
| pH | 1.2 (0.1 M aqueous solution)(Lit.) |
| Refractive Index | n20/D 1.62(Lit.) |
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