Demecolcine ≥98%, pale yellow powder

Supplier: Test
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

Danger

0219019501 0219019505 0219019510 0219019550
IC19019501EA 82.77 USD
IC19019501 IC19019505 IC19019510 IC19019550
Demecolcine ≥98%, pale yellow powder
Demecolcine

Demecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic.
Demecolcine is an antineoplastic agent used to immobilize chromosomes by inactivating the spindle fiber mechanism during metaphase. Medically, Demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle.
Demecolcine depolymerizes microtubules; blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.


  • Presentation: Pale Yellow Powder
  • Soluble in acidified water, alcohol, ether, chloroform (10 mg/mL - clear, faint yellow solution) and benzene.
  • Store at +4 °C.


Demecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic.

Formula: C₂₁H₂₅NO₅
Melting Pt: 186 °C (lit.)
Storage Temperature: Refrigerator
MDL Number: MFCD00075459
CAS Number: 477-30-5
UN: 2811
ADR: 6.1,II

Order Now

Specification Test Results

Identity Test Passes
Purity ≥98%
FTIR Conforms to Standard

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR