Gentamicin sulfate USP
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Synonyms:
Gentamicin sulfate salt, NMD Inhibitor II, Garamycin, Gentamicin sulphate salt, Gentiomycin C
Gentamicin sulfate is an aminoglycoside antibiotic complex produced by fermentation of Micromonospora purpurea or M
- USP Grade
- Presentation: White Powder
- H2O: soluble 50 mg/mL
- Loss on drying: ≤18.0 %
- Optical rotation: +107° to +121° (10 mg/mL, water)
- pH: 3.5 - 5.5 (1 in 25, in water)
Gentamicin sulfate is used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms.
Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface. Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria.
echinospora. It is a mixture of 3 major components designated as C1, C1a, and C2. Gentamicin is used as the sulfate salt. Each component consists of five basic nitrogens and requires five equivalents of sulfuric acid per mole of gentamicin base.
White
Soluble in Water (50 mg/mL)
Melting Pt:
218…237 °C Storage Temperature: Refrigerator |
MDL Number:
MFCD00270181 CAS Number: 1405-41-0 |
Specification Test Results
Identity Test A | Passes |
Identity Test B | Passes |
Potency (dry basis) | ≥590 μg/mg |
Optical Rotation (10 mg/ml, water) | +107° to +121° |
3.5-5.5 | |
Loss on Drying | ≤18.0% |
Residue on Ignition | ≤1.0% |
Limit of Methanol | ≤1.0% |
Content of Gentamicins |
C1 = 25 - 50% C1a = 10 - 35% C2 + C2a = 25 - 55% |
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