4-Thiouridine ~98%, white powder

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0215213405 0215213425 0215213480
IC15213405EA 55.5 USD
IC15213405 IC15213425 IC15213480
4-Thiouridine ~98%, white powder
4-Thiouridine

Soluble in water (20 mg/mL-clear, dark yellow solution).


4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA. Because 4-thio-rU is photoreactive, 4-thio-rU modified RNA oligos have also been used as photoaffinity probes in the role of substrate analogs for characterizing the enzyme:substrate complex of tRNA:pseudouridine-5S synthase . 4-thio-rU modified oligos have also been used as modules for assembling U25 small nucleolar RNAs (U25snoRNA) by ligation. These snoRNAs were used in cross-linking studies to identify which proteins assembled on them in vivo in Xenopus oocytes. In addition, because the thiol group is chemically reactive, other moieties can be conjugated at the thiol group of 4-thio-rU. Such a strategy was used to introduce spin labels to 4-thio-rU-containing RNA oligos.


Soluble in water (20 mg/ml - clear, dark yellow solution).


Caution: Research Use Only (RUO).

Formula: C₉H₁₂N₂O₅S
MW: 260.264 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00006538
CAS Number: 13957-31-8

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Specification Test Results

Identity Test Passes
Purity ~98%


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