Valinomycin 93, Solid
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A metabolite with a broad antibiotic spectrum
- Presentation: White
- Freely soluble in petroleum ether, ether, benzene, chloroform, glacial acetic, butyl acetate; soluble in methanol (5 mg/ml-clear, colorless solution) and DMSO (≥10 mg/mL); practically insolubable in water.
Valinomycin, is used as a potassium ionophore shown to induce cell death. Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.
K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.
Inhibitor of mitochondrial action. Valinomycin is a cyclododecadepsipeptide potassium-selective ionophore. It is an antibiotic that was originially isolated from various strains of Streptomyces. The hydrophilic interior is the right size to accommodate the potassium ion, but not other ions, while the hydrophobic exterior allows the complex to pass through the lipid bilayer. Valinomycin induces apoptosis in several cell types, including CHO cells, by stimulating potassium efflux. Apoptotic events produced by valinomycin include phosphatidylserine membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization. Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.
White crystalline powder
Freely soluble in petroleum ether, ether, benzene, chloroform, glacial acetic, butyl acetate; soluble in methanol (5 mg/mL-clear, colorless solution) and DMSO (≥10 mg/mL); practically insolubable in water
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Formula:
C₅₄H₉₀O₁₈N₆ MW: 1111.34 g/mol Melting Pt: 184…190 °C Storage Temperature: Refrigerator |
MDL Number:
MFCD00005114 CAS Number: 2001-95-8 ADR: 6.1 I |
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