L(+)-Histidine ≥99%, crystalline powder
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L-histidine is an essential amino acid with a basic side chain, and is hydrophilic in character
Precursor of histamine by action of histidine decarboxylase.
It contains an imidazole group in the side chain. Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. In turn, histidine is degraded to glutamate by histidase, urocanase, and imidazolonepropionase via the formation of urocanate, 4-imidazolone 5-propionate, and N-formiminoglutamate.
L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilized as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. It is generally used in media preparation.
Soluble 50 mg/mL in 0,5 M HCl.
Formula:
C₆H₉N₃O₂ |
MDL Number:
MFCD00064315 CAS Number: 71-00-1 |
Specification Test Results
Synonyms | Glyoxaline-5-Alanine; (S)-2-Amino-3-(4-imidazolyl)propionic acid |
Form | White Crystalline Powder |
Storage | Store at Room Temperature. |
Optical Rotation | 11.0° to 13.5° (c=10, 4N HCl) |
pH | 7.0 - 8.5 (1% aq soln) |
Solubility | Soluble 50 mg/mL in 0.5 M HCl. |
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