Cycloheximide Microbial 94, powder_white

Supplier: Test
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

0210018301 0210018305 0210018325
IC10018301EA 103.99 USD
IC10018301 IC10018305 75875-620
Cycloheximide Microbial 94, powder_white
Cycloheximide

Applications
Cycloheximide is used in protein synthesis in apoptosis. It is also used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production.
Product Description
Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. It inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis.
Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.


Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. It inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis.


Very soluble in chloroform, methanol, and acetone; moderately soluble in isopropanol, n-butanol and amyl acetate; very slightly soluble in carbon tetrachloride and the saturated hydrocarbons. Cycloheximide solubility in water is about 2% and the solutions are stable for several weeks at pH 3-5 which is the optimum range for stability. Activity is rapidly destroyed by alkaline solutions

Formula: C₁₅H₂₃NO₄
MW: 281.35
MDL Number: MFCD00082346
CAS Number: 66-81-9
UN: 2811
ADR: 6.1 I
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=3abdf7ad3f7b3ea9e67fba3b6f3970c6627794be&vid=3abdf7ad3f7b3ea9e67fba3b6f3970c6627794be&prid=web&clid=SAPDAM https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=0ba9cd196873904f59b3d93d22d58445e449fb54&vid=0ba9cd196873904f59b3d93d22d58445e449fb54&prid=web&clid=SAPDAM

Order Now

Specification Test Results

Identity Test Passes
Source Microbial
Purity (HPLC) >94%
FTIR Conforms to Standard
Melting Point 103 - 120°C


Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR