Anti-MLH1 Mouse Monoclonal Antibody [clone: G168-15]

Supplier: Diagnostic Biosystems

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Anti-MLH1 Mouse Monoclonal Antibody [clone: G168-15]

Anti-MLH1 Mouse Monoclonal Antibody [clone: G168-15]

MOB430-05 MOB430 PDM148

95024-680EA 500.68 USD

95024-680 99990-794 95029-770

Anti-MLH1 Mouse Monoclonal Antibody [clone: G168-15]

Antibodies

The G168-15 antibody recognizes human and mouse MLH1 (80-85kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Type:
Antigen: MLH1
Clonality: Monoclonal
Clone: G168-15
Conjugation:
Epitope:
Host: Mouse
Isotype:
Reactivity:

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