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Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
Catalog Number: 89157-932
Supplier: Enzo Life Sciences


Description: CAS Number: 133550-30-8 MDL Number: MFCD00236452 Molecular Formula: C17H14N2O3 Molecular Weight: 294.31 Purity/Analysis Method: <gt/>98.0% (HPLC,T) Form: Crystal Color: Slightly Pale Yellow Melting point (°C): 215 Storage Temperature: <lt/>0°C
Catalog Number: TCT2962-1G
Supplier: TCI America

Description: Tyrphostin AG 490 98%
Catalog Number: 77012-776
Supplier: AMBEED, INC


Description: AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells
Catalog Number: ALA126525250MG
Supplier: ALADDIN SCIENTIFIC

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