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Divided into compartments with a platform in the middle, the horizontal electrophoresis systems completely submerge plated gel platforms in a buffer. In each compartment, electrodes produce the electric field to cause the molecules to travel through the casted gel for DNA and RNA fragment separation. For DNA sequencing, these negatively charged DNA molecules migrate through the gel pores from the negative end to the positive charged en of the gel. Capable of simultaneously running multiple samples, the equipment recirculates buffer efficiently to prevent ionic gradient formation. The high-throughput horizontal electrophoresis systems include color-coding combs and strips for easy loading.