Description: HSF4 belongs to the HSF family. HSF4 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE). The isoform HSF4A represses transcription while the isoform HSF4B activates transcription. HSF4 is a homotrimer which exhibits constitutive DNA binding and forms trimers even in the absence of stress. It is expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. Mutation of HSF4 will cause lamellar cataract which is known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds. Inheritance of these forms of cataract is autosomal dominant.

Catalog Number: 10081-866

Supplier: Proteintech

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Description: HSF4 belongs to the HSF family. HSF4 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE). The isoform HSF4A represses transcription while the isoform HSF4B activates transcription. HSF4 is a homotrimer which exhibits constitutive DNA binding and forms trimers even in the absence of stress. It is expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. Mutation of HSF4 will cause lamellar cataract which is known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds. Inheritance of these forms of cataract is autosomal dominant.

Catalog Number: 10081-212

Supplier: Proteintech

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Description: HyClone™ iron-supplemented bovine calf serum contains additional iron to boost serum transferrin levels to physiological levels.

Catalog Number: 76237-684

Supplier: GE Healthcare - HyClone

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Description: heatstable enterotoxin 1 [Escherichia coli]

Catalog Number: 10671-274

Supplier: Bioss

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Description: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4(HSF4) (By similarity). Highest levels within the nervous system, expressed in different tissues, mostly in intestine, placenta and lung. Increased expression during development. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.

Catalog Number: 10364-014

Supplier: Bioss

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Description: The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Catalog Number: 89135-324

Supplier: Enzo Life Sciences

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Description: The Boekel Scientific line of refrigerated incubators utilize Peltier cooling technology, which alleviates the need for refrigerant and provides a long service life.

Catalog Number: 76269-642

Supplier: Boekel

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Description: Convenient antibody diluent/blocking solution concentrate containing 2% nonfat milk in a borate buffer.

Catalog Number: 95059-192

Supplier: KPL

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Description: Ampac’s polyester/polyethylene laminated tubular rollstock features the same properties as our laminated pouches. Since all tubular rollstock can be cut to any length,it allows for evidence of many different sizes to be collected and sealed for laboratory testing and long-term storage.

Catalog Number: 11213-800

Supplier: Ampac Flexibles

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Description: The exciting demonstrations connect students to core physics and physical science concepts.

Catalog Number: 470018-086

Supplier: INDUSTRIAL SUPPORT INC.

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Description: Niptec 1000 Series lightweight cutters are designed with ergonomically designed ESD safe grips provide excellent operator comfort. Due to the small size of the cutting blades, which are angled at 21°, this compact tool can produce a very fine, flush cut.

Catalog Number: 47743-104

Supplier: Aven Tools

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Description: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Catalog Number: 75793-608

Supplier: Prosci

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Description: ThermalSeal A sealing films are an advanced version of Excel Scientific's classic ThermalSeal sealing films for PCR. ThermalSeal A films consist of 50 m thick clear polypropylene with a thicker 50 m layer of a stronger adhesive formulated for improved protection against evaporation and leakage during thermal cycling.

Catalog Number: 490007-374

Supplier: Excel Scientific

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Description: Samco™ General-Purpose Transfer Pipettes feature a built-in pipette bulb that eliminates the need for plugging, packaging, and autoclaving.

Catalog Number: 14670-418

Supplier: Thermo Fisher Scientific

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Description: Blocking Buffer Sampler Kit for ELISA, immunoassays, and western blot

Catalog Number: 10800-390

Supplier: Rockland Immunochemical

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Description: Recommended Applications: IHC, ISH (in situ hybridization)

Catalog Number: 76201-850

Supplier: Enzo Life Sciences

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