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Tyr-(D-Dab⁴,Arg⁵,D-Trp⁸)-Cyclo-Somatostatin-14 (4-11) Trifluoroacetate

Description: High affinity ligand for all five somatostatin receptors (sst1-sst5). In AtT-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (H-1490) and octreotide (H-5972). In a model of epileptogenesis, however, KE 108 did not exhibit antiepileptic activity suggesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand.
Catalog Number: H-6276.0001BA
Supplier: Bachem Americas
Image Unavailable-H-8430.1000BA

Human;Mouse;Pig;Rat;Sheep PACAP-38 Trifluoroacetate

Description: Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
Catalog Number: H-8430.1000BA
Supplier: Bachem Americas
Image Unavailable-H-7226.0005BA

Cyclo(-Arg-Gly-Asp-D-Phe-Cys) Acetate

Description: c(RGDfC), a RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RGDfC) can be easily conjugated to drugs as combretastatin or surfaces. For the control peptide c(RADfC) see H-7232
Catalog Number: H-7226.0005BA
Supplier: Bachem Americas
Image Unavailable-A-2910.0005BA

Boc-Glu(Osu)-Otbu

Description: Sequence: Boc-Glu(OSu)-OtBu
Catalog Number: A-2910.0005BA
Supplier: Bachem Americas
Image Unavailable-B-4090.0005BA

Fmoc-Asn(Trt)-Ser(Psi(Me,Me)pro)-OH

Description: These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.
Catalog Number: B-4090.0005BA
Supplier: Bachem Americas
Image Unavailable-E-2930.0001BA

(R)-2-Amino-3-(tritylthio)propanamide

Description: Sequence: H-Cys(Trt)-NH₂
Catalog Number: E-2930.0001BA
Supplier: Bachem Americas
Image Unavailable-H-4636.0005BA

(Des-Gly¹⁰,D-Leu⁶,D-Leu⁷,Pro-NHEt⁹)-LHRH Trifluoroacetate

Description: LHRH is also called Gonadotropin-Releasing Hormone (GnRH) or Luteinizing Hormone-Releasing Factor (LRF).
Catalog Number: H-4636.0005BA
Supplier: Bachem Americas
Image Unavailable-G-1300.0005BA

H-Ala-Met-OH, Bachem

Description: 1G CAS: 14486-05-6 C8H16N2O3S FW: 220.29
Catalog Number: G-1300.0005BA
Supplier: Bachem Americas
Image Unavailable-G-3910.0250BA

Pyr-Phe-OH

Description: Substrate for pyroglutamyl peptidase I.
Catalog Number: G-3910.0250BA
Supplier: Bachem Americas
Image Unavailable-F-1025.0001BA

cis-4-Hydroxy-L-(-)-proline

Description: Sequence: H-cis-Hyp-OH
Catalog Number: F-1025.0001BA
Supplier: Bachem Americas
Image Unavailable-B-1340.0100BA

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine

Description: Sequence: Fmoc-Ile-OH
Catalog Number: B-1340.0100BA
Supplier: Bachem Americas
Image Unavailable-F-1185.0005BA

DL-α-Aminoadipic acid

Description: Sequence: H-DL-Aad-OH
Synonym(s): DL-α-Aminoadipic acid#(RS)-2-Aminohexanedioic acid#H-DL-Homoglu-OH
Catalog Number: F-1185.0005BA
Supplier: Bachem Americas
Image Unavailable-G-3090.0001BA

Pyr-Ala-OH

Description: Substrate for pyroglutamyl peptidase I.
Catalog Number: G-3090.0001BA
Supplier: Bachem Americas
Image Unavailable-H-6382.1000BA

(Pyr¹¹)-beta-Amyloid (11-40)

Description: pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.
Catalog Number: H-6382.1000BA
Supplier: Bachem Americas
Image Unavailable-I-1140.0100BA

N-Cbz-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride

Description: Sequence: Z-Gly-Gly-Arg-AMC · HCl
Catalog Number: I-1140.0100BA
Supplier: Bachem Americas
Image Unavailable-H-2502.0500BA

Vasonatrin Peptide Trifluoroacetate

Description: Vasonatrin peptide is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Its sequence represents the 22 amino acids of CNP plus the 5 C-terminal amino acids of ANP. It possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions associated neither with ANP nor with CNP.
Catalog Number: H-2502.0500BA
Supplier: Bachem Americas
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