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Anti-CCNE1 Mouse Monoclonal Antibody [clone: HE12]

Supplier: Diagnostic Biosystems
Description: This antibody recognizes a doublet of 50 kDa and a single band of 42 kDa identified as cyclin E. Cyclin proteins are a family of related proteins, which control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and is modulated by the presence of tumor suppressor proteins such as p16.

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Anti-S100 Polyclonal Antibody

Supplier: Diagnostic Biosystems
Description: This antibody reacts with cow S-100 protein a and b. It shows strong cross-reactivity with human S-100 a and b. In the brain, it labels glial and ependymal cells. Melanocytes and Langerhans cells of the skin stain positive with this antibody.

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Anti-CD1A Mouse Monoclonal Antibody [clone: O10]

Supplier: Diagnostic Biosystems
Description: This antibody reacts with a 49 kDa protein. At least five CD1 genes are identified (CD1a, b, c, d and e). This antibody reacts with cortical thymocytes, Langerhans cells in epidermis, dendritic cells of dermis and Langerhans cells of mucosa of tonsil. This antibody may be useful in the characterization of leukemias and lymphomas.

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Anti-PRAME Rabbit Monoclonal Antibody [clone: EPR20330]

Catalog Number: (76634-888)
Supplier: Diagnostic Biosystems
Description: PRAME (Preferentially expressed Antigen in Melanoma) is a tumorassociated antigen and is a member of the family of cancer testis antigens (CTA). PRAME is expressed in malignant cells, including leukaemias, Hodgkin's lymphoma, breast cancer, and primary and metastatic melanomas. PRAME has low or no expression in normal tissues except for in testis, ovary, placenta, adrenals and endometrium.
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Anti-Insulin Mouse Monoclonal Antibody [clone: K36aC10]

Supplier: Diagnostic Biosystems
Description: This antibody recognizes purified insulin from the pancreas of human, as well as proinsulin from human.

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Anti-CD3 Mouse Monoclonal Antibody [clone: LN10]

Supplier: Diagnostic Biosystems
Description: The clone F7.2.38 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone F7.2.38 recognizes T cells in the thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kDa. The CD3 antigen is first detected in early thymocytes, and its appearance probably represents one of the earliest signs of commitment to the T cell lineage.

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Anti-BCL10 Mouse Monoclonal Antibody [clone: 151]

Supplier: Diagnostic Biosystems
Description: Monoclonal Anti-BCL-10 reacts specifically with human bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human bcl-10 molecule. BCL-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (caspase recruitment domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (VCLAP). BCL-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, P38, and NF-kB activation. Deregulation of BCL-10 expression was also demonstrated to be involved in cellular oncogenesis.

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Anti-Cytokeratin AE1 Acidic Mouse Monoclonal Antibody [clone: AE1]

Catalog Number: (76634-296)
Supplier: Diagnostic Biosystems
Description: Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pH <5.7) and basic (pH >6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad-spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g., squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
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Anti-Calponin Mouse Monoclonal Antibody [clone: CALP]

Supplier: Diagnostic Biosystems
Description: This antibody reacts with a 34 kDa protein known as calponin. Calponin, a calmodulin, binds tropomyosin and F-actin and is thought to be involved in the regulation of smooth muscle contraction. Expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist whose molecular weights are 34 kDa and 29 kDa. 29 kDa isoform is primarily restricted to the muscle of the urogenital tract.

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Anti-CD45RO T cell Mouse Monoclonal Antibody [clone: UCHL-1]

Supplier: Diagnostic Biosystems
Description: This antibody reacts with a 180 kDa glycoprotein of the CD45 family, found on most thymocytes and activated T cells but only on a portion of the resting T cells. It reacts with most thymocytes, a subpopulation of resting cells within both the CD4 and CD8 subsets and mature activated T cells.

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Anti-Smooth muscle myosin Mouse Monoclonal Antibody [clone: SMMS-1]

Supplier: Diagnostic Biosystems
Description: Monoclonal anti-smooth muscle myosin reacts with myosin heavy chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or non-muscle myosin. In immunohistochemistry it stains vascular and visceral smooth muscle cells and cells that have smooth muscle-like characteristics.

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Anti-Heat Shock Protein 70 Mouse Monoclonal Antibody [clone: W27]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to constitutive (HSP73) and inducible (HSP72) form of HSP70. HSP70 is found to be associated with steroid receptors, actin, P53, polyoma T antigen, nucleotides and other known proteins. HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs and other damaging conditions.

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Anti-Lysozyme Polyclonal Antibody

Supplier: Diagnostic Biosystems
Description: This antibody reacts with lysozyme. It stains granulocytes, monocytes and macrophages in human tonsil, skin and colon. This antibody does not cross-react with any other cell types.

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Anti-Progesterone receptor (PR) Rabbit Monoclonal Antibody [clone: SP2]

Catalog Number: (76634-840)
Supplier: Diagnostic Biosystems
Description: The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
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Anti-CD4 Rabbit Monoclonal Antibody [clone: EP204]

Catalog Number: (76634-878)
Supplier: Diagnostic Biosystems
Description: CD4 is glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with antigen-presenting cell and also interacts directly with MHC class II molecules of the surface of antigen presenting cells. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NL/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory legions and malignant lymphomas.
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Anti-Inhibin Mouse Monoclonal Antibody [clone: R1]

Catalog Number: (76634-454)
Supplier: Diagnostic Biosystems
Description: Inhibin is a dimeric glycoprotein hormone from the TGF-β family made of α and β subunits. This antibody recognizes the 32kDa α subunit of human inhibin. Inhibin α is expressed in a wide variety of human tissues, such as brain, prostate, adrenal, granulose cells of ovary, sertoli cells of testis and in fetoplacental unit.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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